Enara Bio’s purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT™ platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens™. We are using our proprietary bispecific T-cell engager platform (EnTiCE) to target Dark Antigens for the treatment of patients with a broad range of solid tumors.

Enara Bio was founded in 2016 and backed by leading financial and corporate strategic investors from the UK, US and EU. The company is based in Oxford, UK.

Role Overview 

We are seeking a talented and driven Bioinformatics Data Scientist to join our multidisciplinary research team. This role is ideal for someone with a strong background in bioinformatics and a passion for applying computational methods to advance cancer immunotherapy. You will play a key role in developing and deploying scalable workflows to analyse high-dimensional omics data, helping uncover novel targets and biomarkers that drive our therapeutic pipeline.

Key Responsibilities 

• Develop and maintain reproducible bioinformatics workflows using Python and Nextflow to support R&D efforts, focusing on high-dimensional datasets such as bulk and single cell RNA-seq.
• Analyse complex datasets from cancer immunotherapy studies to identify therapeutic targets, immune signatures, and predictive biomarkers.
• Collaborate closely with immunologists, molecular biologists, and data scientists to translate computational findings into actionable insights.
• Apply machine learning techniques to discovery or translational research.
• Contribute to scientific publications, internal reports, and presentations that drive strategic decisions.

Required Qualifications and experience

• PhD or MSc in Computational Biology, Bioinformatics, Systems Biology, or a related field.
• Proven experience in oncology and omics data analysis.
• Proficiency in Python and workflow management tools such as Nextflow.
• Strong statistical and data visualization skills.
• Familiarity with public datasets (e.g., TCGA, GTEx, Human Cell Atlas) and cloud-based computing environments.
• Strong communication and organizational skills, with the ability to work in a collaborative, fast-paced environment.

Preferred skills

• Experience with TCR-seq, RIBO-seq or proteomics.
• Experience with machine learning frameworks (e.g., scikit-learn, TensorFlow, XGBoost).
• Knowledge of immunology and tumor microenvironment biology.
• Experience with containerization (Docker) and version control (Git).

Further information:

The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos:

Empowerment: We promote autonomy across Enara rejecting conventional hierarchy. We engage each other through transparency, collaboration and trust. We each take action with a deep sense of personal and shared accountability.

Courage: We push boundaries in all that we do to deliver on our purpose. We make bold decisions, embrace risk and tackle challenges to advance our novel science. Courage is essential for everything we do.

Humility: We are proud of and excited by our novel science, but we acknowledge that we cannot know everything. Our curiosity drives us to continually learn from each other & the outside world irrespective of our role or title. We give and receive feedback with no room for ego.

Growth: We invest in our people, culture and community to foster belonging as a foundation for success. We embrace individual development to create deeper personal fulfilment and drive stronger collective impact.

We offer a mission-driven company with a bold vision for cancer immunotherapy; hybrid working with flexibility to work remotely and on-site in Oxford; access to cutting-edge technologies and datasets; competitive compensation and benefits and opportunities for career growth, publication, and impact.

Applicants should be able to demonstrate proof of the right to work in United Kingdom.

Enara Bio Limited is an equal opportunities employer.

Application deadline: Wednesday 29 October 2025 - we encourage early applications as shortlisting may commence ahead of the closing date.